Boosting host immune defenses to treat tuberculosis

A study in iScience suggests a new approach that might help treat Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis: making people's cells better at killing Mtb by harnessing RNA sensors in our cells, which detect the RNA of invading pathogens. For the first time, researchers led by Anne Goldfeld, MD, of Boston Children's Hospital's Program in Cellular and Molecular Medicine, showed that RNA sensing is important in inhibiting Mtb's growth once it gets inside cells.