244 articles from WEDNESDAY 13.11.2019

Endocytosis, a fundamental process that cells use to take in macromolecules, functions a lot like an airlock on a spaceship -- but squishier, says a researcher. Researchers have studied how cells initiate and perform endocytosis since the 1960s, but in a new article they finally describes how cells shut down this important cellular machinery. And their findings are not without controversy.

After visiting asteroid, Japan’s Hayabusa 2 probe heads back to Earth with samplesJapan's Hayabusa 2 spacecraft and its science team bid a bittersweet farewell to the asteroid Ryugu, 180 million miles from Earth, and began the months-long return trip to Earth with a precious set of samples. "This is an emotional moment!" the team tweeted on Tuesday. “It's sad to say goodbye to Ryugu,” project manager Yuichi Tsuda said at the Japan Aerospace Exploration Agency's command center. “Literally it has been at the center of our lives over the past one and a half years.” The farewell isn't finished quite yet, however. Over the next few days, Hayabusa 2's camera will capture… Read More


Researchers have succeeded in reconstructing the evolutionary relationship between a two million year old giant primate and the living orangutan. It is the first time genetic material this old has been retrieved from a fossil in a subtropical area. This allows the researchers to accurately reconstruct animal, including human, evolutionary processes way beyond the limits known today.

Over 77,000 Canadians are living with multiple sclerosis, a disease whose causes still remain unknown. Presently, they have no hope for a cure. Researchers have now identified a molecule named ALCAM which, once blocked, delays the progression of the disease. Their results, obtained from in vitro human and in vivo mouse studies, could lead to the development of a new generation of therapies to treat this autoimmune disease.

The ratio of carbon isotopes in three common species of tuna has changed substantially since 2000, suggesting major shifts are also taking place in the phytoplankton populations that form the basis of the ocean's food web, according to a new international study. Much of the change occurring in phytoplankton physiology and species composition may be driven by increased ocean stratification, an impact of climate change, the study suggests.

A novel microfluidic device addresses one of the most costly steps in the engineered cell therapy manufacturing process, namely gene delivery. Deterministic mechanoporation, or DMP, uses fluid flow to pull each cell in a large population onto its own tiny needle. The flow is then reversed to release the cells from the needles, leaving a singular and precisely defined pore within each cell that allows for gene delivery. Eliminating viral vectors can substantially reduce cost.